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tcl-2 T-cell defective protein 2 [ Caenorhabditis elegans ]

Gene ID: 176832, updated on 2-Nov-2024

Summary

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Official Symbol
tcl-2
Official Full Name
T-cell defective protein 2
Primary source
WormBase:WBGene00006561
Locus tag
CELE_Y38C1AA.4
See related
AllianceGenome:WB:WBGene00006561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in asymmetric cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including TL.a; TL.p; TR.a; inner labial neurons; and seam cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tcl-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (179083..183254)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene nicotinamidase Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene COP9 signalosome complex subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. Zhao X, et al. Dev Biol, 2003 Apr 15. PMID 12679102
  2. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article
  3. Wnt signaling. Eisenmann DM. WormBook, 2005 Jun 25. PMID 18050402, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functions with Wnt pathways to control T cell fate specification, gonad development, and P12 cell fate specification.
    Title: tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell defective protein 2
NP_001294305.1
  • Confirmed by transcript evidence
NP_499875.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    179083..183254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067474.7 → NP_499875.2  T-cell defective protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499875.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N428

  2. NM_001307376.3 → NP_001294305.1  T-cell defective protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB86
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N428.3

Gene LinkOut

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