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pnc-1 nicotinamidase [ Caenorhabditis elegans ]

Gene ID: 176833, updated on 2-Nov-2024

Summary

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Official Symbol
pnc-1
Official Full Name
nicotinamidase
Primary source
WormBase:WBGene00021395
Locus tag
CELE_Y38C1AA.3
See related
AllianceGenome:WB:WBGene00021395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables nicotinamidase activity. Involved in nicotinamide metabolic process. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including coelomocyte; epithelial cell; ganglia; gland cell; and pharyngeal cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pnc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (184484..192151)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene T-cell defective protein 2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene COP9 signalosome complex subunit 3 Neighboring gene GTP cyclohydrolase 1 feedback regulatory protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans. Wang W, et al. J Biol Chem, 2015 Oct 23. PMID 26350462, Free PMC Article
  2. An NAD(+) biosynthetic pathway enzyme functions cell non-autonomously in C. elegans development. Crook M, et al. Dev Dyn, 2014 Aug. PMID 24753121, Free PMC Article
  3. Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans. Vrablik TL, et al. Dev Biol, 2011 Jan 15. PMID 21092737, Free PMC Article
  4. Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans. Vrablik TL, et al. Development, 2009 Nov. PMID 19820182, Free PMC Article
  5. Uridine monophosphate synthetase enables eukaryotic de novo NAD(+) biosynthesis from quinolinic acid. McReynolds MR, et al. J Biol Chem, 2017 Jul 7. PMID 28559281, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nicotinamide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nicotinamidase
NP_001367799.1
  • Confirmed by transcript evidence
NP_499876.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    184484..192151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067475.4 → NP_499876.1  nicotinamidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N426
    Conserved Domains (1) summary
    cd01011
    Location:92 → 310
    nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...

  2. NM_001379995.2 → NP_001367799.1  nicotinamidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7WK39
    Conserved Domains (1) summary
    cd01011
    Location:72 → 290
    nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
Nucleotide Protein
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