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pqbp-1.1 WW domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176847, updated on 2-Nov-2024

Summary

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Official Symbol
pqbp-1.1
Official Full Name
WW domain-containing protein
Primary source
WormBase:WBGene00020647
Locus tag
CELE_T21D12.3
See related
AllianceGenome:WB:WBGene00020647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribonucleoprotein complex binding activity. Involved in triglyceride metabolic process. Located in nuclear body. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pqbp-1.1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (259989..261683, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Exonuclease domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Paralyzed arrest at two-fold protein 6 Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. Takahashi K, et al. PLoS One, 2009. PMID 19119319, Free PMC Article
  2. Big ideas for small brains: what can psychiatry learn from worms, flies, bees and fish? Burne T, et al. Mol Psychiatry, 2011 Jan. PMID 20351718
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WW domain-containing protein
NP_499890.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    259989..261683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067489.5 → NP_499890.2  WW domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499890.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16786
    Conserved Domains (1) summary
    smart00456
    Location:90 → 122
    WW; Domain with 2 conserved Trp (W) residues
Nucleotide Protein
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