sma-10 Leucine-rich repeats and immunoglobulin-like domains protein sma-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sma-10
Official Full Name: Leucine-rich repeats and immunoglobulin-like domains protein sma-10
Primary source: WormBase:WBGene00020649
Locus tag: CELE_T21D12.9
See related: AllianceGenome:WB:WBGene00020649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables type I transforming growth factor beta receptor binding activity and type II transforming growth factor beta receptor binding activity. Involved in several processes, including positive regulation of transforming growth factor beta receptor signaling pathway; regulation of mesodermal cell fate specification; and transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Is expressed in hypodermis; intestine; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to several human genes including LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sma-10 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (274589..279940)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the loss of sma-10 leads to aberrant endocytic trafficking of SMA-6, resulting in its accumulation in distinct intracellular endosomes. These results suggest a possible mechanism for its regulation of BMP signaling.
Title: C. elegans SMA-10 regulates BMP receptor trafficking.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21D12.9 (e-PCR)
- UniSTS:317532

T21D12.6 (e-PCR)
- UniSTS:305899

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables type I transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type II transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Leucine-rich repeats and immunoglobulin-like domains protein sma-10

NP_001367941.1

Confirmed by transcript evidence

NP_499896.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

274589..279940

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380001.2 → NP_001367941.1 Leucine-rich repeats and immunoglobulin-like domains protein sma-10 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

PLN00113
Location:32 → 375

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:197 → 220

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:339 → 427

LRR_8; Leucine rich repeat

cd00096
Location:624 → 628

Ig; Ig strand A' [structural motif]

cl11960
Location:618 → 705

Ig; Immunoglobulin domain
NM_067495.9 → NP_499896.1 Leucine-rich repeats and immunoglobulin-like domains protein sma-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499896.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0D4, Q965M2

Conserved Domains (9) summary

cd00096
Location:522 → 606

Ig; Immunoglobulin domain

smart00013
Location:29 → 54

LRRNT; Leucine rich repeat N-terminal domain

smart00409
Location:719 → 788

IG; Immunoglobulin

cd00116
Location:100 → 303

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam07679
Location:616 → 705

I-set; Immunoglobulin I-set domain

sd00033
Location:197 → 220

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:78 → 116

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:172 → 231

LRR_8; Leucine rich repeat

cl11960
Location:633 → 705

Ig; Immunoglobulin domain