nog-1 Nucleolar GTP-binding protein 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: nog-1
Gene description: Nucleolar GTP-binding protein 1
Locus tag: CELE_T07A9.9
See related: AllianceGenome:WB:WBGene00020297
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of lipid storage; and regulation of insulin receptor signaling pathway involved in determination of adult lifespan. Located in nucleolus. Is expressed in several structures, including excretory cell; germ cell; intestine; pharynx; and vulva. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nog-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (393880..396420)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nog-1 in C. elegans may be an important player in regulating life span and fat storage via the insulin/IGF pathway.
Title: Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07A9.9 (e-PCR)
- UniSTS:310713

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nucleolar GTP-binding protein 1

NP_741288.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

393880..396420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171242.6 → NP_741288.1 Nucleolar GTP-binding protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741288.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44411, Q8MXI6

Conserved Domains (3) summary

cd01897
Location:170 → 341

NOG; Nucleolar GTP-binding protein (NOG)

COG1084
Location:3 → 346

Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]

pfam08155
Location:445 → 495

NOGCT; NOGCT (NUC087) domain