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ech-5 Enoyl-CoA hydratase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176908, updated on 2-Nov-2024

Summary

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Official Symbol
ech-5
Official Full Name
Enoyl-CoA hydratase, mitochondrial
Primary source
WormBase:WBGene00001154
Locus tag
CELE_F56B3.5
See related
AllianceGenome:WB:WBGene00001154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydro-lyase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in pharynx. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase) and ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ech-5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (797023..799920)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Skp1-related protein Neighboring gene Mitochondrial import inner membrane translocase subunit Tim21;TIM21-like protein, mitochondrial Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein mL46 Neighboring gene SRR1-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  2. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Enoyl-CoA hydratase, mitochondrial
NP_499993.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    797023..799920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067592.7 → NP_499993.2  Enoyl-CoA hydratase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499993.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45106
    Conserved Domains (1) summary
    cl23717
    Location:39 → 287
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
Nucleotide Protein
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