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lep-2 E3 ubiquitin-protein ligase makorin [ Caenorhabditis elegans ]

Gene ID: 176918, updated on 2-Nov-2024

Summary

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Official Symbol
lep-2
Official Full Name
E3 ubiquitin-protein ligase makorin
Primary source
WormBase:WBGene00002278
Locus tag
CELE_Y55F3AM.6
See related
AllianceGenome:WB:WBGene00002278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in developing hermaphrodite gonad; hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1); MKRN2 (makorin ring finger protein 2); and MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lep-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (992283..997644)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sema domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system. Lawson H, et al. Elife, 2019 Jul 2. PMID 31264582, Free PMC Article
  2. The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28. Kiontke KC, et al. Dev Cell, 2019 May 20. PMID 30956008, Free PMC Article
  3. Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans. Herrera RA, et al. Development, 2016 Mar 1. PMID 26811380, Free PMC Article
  4. A sex-specific switch in a single glial cell patterns the apical extracellular matrix. Fung W, et al. Curr Biol, 2023 Oct 9. PMID 37708887, Free PMC Article
  5. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Kaitna S, et al. Curr Biol, 2000 Oct 5. PMID 11050385

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans
    Title: Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.
  2. These studies reveal roles for a Makorin and a lncRNA in timing of sexual differentiation; moreover, they demonstrate deep conservation of the lin-28-let-7 system in controlling the functional maturation of the nervous system.
    Title: The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase makorin
NP_001023510.1
  • Confirmed by transcript evidence
NP_001023511.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    992283..997644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028340.6 → NP_001023511.1  E3 ubiquitin-protein ligase makorin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0R6
    Conserved Domains (2) summary
    PHA03096
    Location:157 → 302
    PHA03096; p28-like protein; Provisional
    cd00162
    Location:212 → 269
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_001028339.6 → NP_001023510.1  E3 ubiquitin-protein ligase makorin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0R6, Q9N373
    Conserved Domains (4) summary
    PHA03096
    Location:157 → 302
    PHA03096; p28-like protein; Provisional
    COG5252
    Location:275 → 331
    COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
    cd16521
    Location:213 → 267
    RING-HC_MKRN; RING finger, HC subclass, found in the makorin (MKRN) protein family
    pfam15663
    Location:1 → 56
    zf-CCCH_3; Zinc-finger containing family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N373.1

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