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cox-18 Cytochrome OXidase assembly protein [ Caenorhabditis elegans ]

Gene ID: 176930, updated on 2-Nov-2024

Summary

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Official Symbol
cox-18
Official Full Name
Cytochrome OXidase assembly protein
Primary source
WormBase:WBGene00021932
Locus tag
CELE_Y55F3AR.1
See related
AllianceGenome:WB:WBGene00021932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cox-18 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (1097453..1102980)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene 8 kDa glycoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Praziquantel inhibits Caenorhabditis elegans development and species-wide differences might be cct-8-dependent. Wit J, et al. PLoS One, 2023. PMID 37561720, Free PMC Article
  2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables membrane insertase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables membrane insertase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cytochrome OXidase assembly protein
NP_500037.2
  • Product from WormBase gene class cox;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1097453..1102980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067636.9 → NP_500037.2  Cytochrome OXidase assembly protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500037.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N356
    Conserved Domains (1) summary
    cl00489
    Location:182 → 282
    60KD_IMP; 60Kd inner membrane protein
Nucleotide Protein
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