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dsl-2 Delta-like protein [ Caenorhabditis elegans ]

Gene ID: 176938, updated on 2-Nov-2024

Summary

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Official Symbol
dsl-2
Official Full Name
Delta-like protein
Primary source
WormBase:WBGene00001104
Locus tag
CELE_W09G12.1
See related
AllianceGenome:WB:WBGene00001104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head and tail. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dsl-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (1202651..1204970, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sphingosine Phosphate Lyase Neighboring gene pseudo Neighboring gene Delta-like protein dsl-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A "latent niche" mechanism for tumor initiation. McGovern M, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564624, Free PMC Article
  2. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Chen N, et al. Dev Cell, 2004 Feb. PMID 14960273
  3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Delta-like protein
NP_500052.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1202651..1204970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067651.7 → NP_500052.1  Delta-like protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45203
    Conserved Domains (1) summary
    smart00051
    Location:102 → 164
    DSL; delta serrate ligand
Nucleotide Protein
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