rpc-11 DNA-directed RNA polymerase subunit;TFIIS-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpc-11
Official Full Name: DNA-directed RNA polymerase subunit;TFIIS-type domain-containing protein
Primary source: WormBase:WBGene00022309
Locus tag: CELE_Y77E11A.6
See related: AllianceGenome:WB:WBGene00022309
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpc-11 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (1408608..1410041, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y77E11A_3443.q (e-PCR)
- UniSTS:324507

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase III transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase subunit;TFIIS-type domain-containing protein

NP_001368279.1

Confirmed by transcript evidence

NP_500076.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1408608..1410041 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067675.5 → NP_500076.1 DNA-directed RNA polymerase subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500076.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N4B7

Conserved Domains (3) summary

smart00661
Location:4 → 53

RPOL9; RNA polymerase subunit 9

COG1594
Location:1 → 108

RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]

cd10509
Location:61 → 108

Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III
NM_001380043.1 → NP_001368279.1 TFIIS-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PMG8

Conserved Domains (1) summary

cl02609
Location:1 → 29

Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit