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ptpn-22 Protein-tyrosine-phosphatase [ Caenorhabditis elegans ]

Gene ID: 176981, updated on 2-Nov-2024

Summary

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Official Symbol
ptpn-22
Official Full Name
Protein-tyrosine-phosphatase
Primary source
WormBase:WBGene00021507
Locus tag
CELE_Y41D4A.5
See related
AllianceGenome:WB:WBGene00021507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to several human genes including PTPN22 (protein tyrosine phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ptpn-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (1727963..1737884, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene CC domain-containing protein Neighboring gene Amidase domain-containing protein;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Neighboring gene Transmembrane 9 superfamily member

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans. Binti S, et al. PLoS Genet, 2024 Aug. PMID 39173071, Free PMC Article
  2. Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans. Meng J, et al. Nat Commun, 2021 Mar 3. PMID 33658510, Free PMC Article
  3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
  4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans.
    Title: A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein-tyrosine-phosphatase
NP_500128.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1727963..1737884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067727.7 → NP_500128.2  Protein-tyrosine-phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500128.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Y26
    Conserved Domains (2) summary
    smart00194
    Location:102 → 365
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:129 → 365
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
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