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Y41D4A.6 Amidase domain-containing protein;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176982, updated on 2-Nov-2024

Summary

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Official Symbol
Y41D4A.6
Official Full Name
Amidase domain-containing protein;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Primary source
WormBase:WBGene00021508
Locus tag
CELE_Y41D4A.6
See related
AllianceGenome:WB:WBGene00021508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y41D4A.6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (1740447..1745503, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene CC domain-containing protein Neighboring gene Protein-tyrosine-phosphatase Neighboring gene Transmembrane 9 superfamily member Neighboring gene BUB1 N-terminal domain-containing protein Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Amidase domain-containing protein;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
NP_001294547.1
  • Confirmed by transcript evidence
NP_001294548.1
  • Confirmed by transcript evidence
NP_001368303.1
  • Confirmed by transcript evidence
NP_001368304.1
  • Confirmed by transcript evidence
NP_001368305.1
  • Confirmed by transcript evidence
NP_500129.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1740447..1745503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067728.7 → NP_500129.1  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500129.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Y25
    Conserved Domains (1) summary
    PRK00012
    Location:20 → 446
    gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed

  2. NM_001307618.3 → NP_001294547.1  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PC78
    Conserved Domains (1) summary
    PRK00012
    Location:20 → 448
    gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed

  3. NM_001380058.1 → NP_001368303.1  Amidase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PF27
    Conserved Domains (1) summary
    cl18951
    Location:2 → 154
    Amidase

  4. NM_001307619.1 → NP_001294548.1  Amidase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMM1
    Conserved Domains (1) summary
    cl18951
    Location:2 → 156
    Amidase

  5. NM_001380059.1 → NP_001368304.1  Amidase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBV0
    Conserved Domains (1) summary
    cl18951
    Location:1 → 133
    Amidase

  6. NM_001380060.1 → NP_001368305.1  Amidase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRY3
    Conserved Domains (1) summary
    cl18951
    Location:1 → 135
    Amidase
Nucleotide Protein
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