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snn-1 ATP-grasp domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176987, updated on 2-Nov-2024

Summary

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Official Symbol
snn-1
Official Full Name
ATP-grasp domain-containing protein
Primary source
WormBase:WBGene00004913
Locus tag
CELE_Y38C1BA.2
See related
AllianceGenome:WB:WBGene00004913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity. Involved in neuromuscular synaptic transmission. Located in presynaptic periactive zone. Is expressed in epithelial cell and nervous system. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders; non-syndromic X-linked intellectual disability 50; and schizophrenia. Orthologous to several human genes including SYN3 (synapsin III). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See snn-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (1805027..1815118, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release. Yu SC, et al. J Neurosci, 2021 May 12. PMID 33820857, Free PMC Article
  2. Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Stavoe AK, et al. Genes Dev, 2012 Oct 1. PMID 23028145, Free PMC Article
  3. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Arantes LP, et al. Toxicol Res (Camb), 2016 Nov 1. PMID 28316775, Free PMC Article
  4. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Patel MR, et al. Nat Neurosci, 2006 Dec. PMID 17115039, Free PMC Article
  5. Synaptogenesis. Jin Y. WormBook, 2005 Dec 16. PMID 18050400, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.
    Title: Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in presynaptic periactive zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-grasp domain-containing protein
NP_001367951.1
  • Confirmed by transcript evidence
NP_001367952.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1805027..1815118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380066.2 → NP_001367951.1  ATP-grasp domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGI2
    Conserved Domains (3) summary
    PRK14950
    Location:293 → 381
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam02078
    Location:5 → 64
    Synapsin; N-terminal domain
    cl17255
    Location:95 → 288
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. NM_001380065.1 → NP_001367952.1  ATP-grasp domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXU3
    Conserved Domains (3) summary
    PRK14950
    Location:366 → 454
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam02078
    Location:78 → 137
    Synapsin; N-terminal domain
    cl17255
    Location:168 → 361
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
Nucleotide Protein
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