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col-109 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176988, updated on 2-Nov-2024

Summary

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Official Symbol
col-109
Official Full Name
Nematode cuticle collagen N-terminal domain-containing protein
Primary source
WormBase:WBGene00000683
Locus tag
CELE_Y38C1BA.3
See related
AllianceGenome:WB:WBGene00000683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See col-109 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (1817392..1820253, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene ATP-grasp domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase type 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly. Novelli J, et al. Genetics, 2006 Apr. PMID 16452136, Free PMC Article
  2. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article
  3. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
  4. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nematode cuticle collagen N-terminal domain-containing protein
NP_500138.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1817392..1820253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067737.6 → NP_500138.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N527
    Conserved Domains (2) summary
    smart01088
    Location:12 → 63
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    PRK07764
    Location:95 → 228
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
Nucleotide Protein
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