U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

egl-18 Putative transcription factor egl-18 [ Caenorhabditis elegans ]

Gene ID: 176992, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
egl-18
Official Full Name
Putative transcription factor egl-18
Primary source
WormBase:WBGene00001186
Locus tag
CELE_F55A8.1
See related
AllianceGenome:WB:WBGene00001186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; membrane fusion; and nematode larval development. Located in nucleus. Is expressed in several structures, including ABprpppppaa; body wall muscle cell from MS lineage; nervous system; seam cell; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See egl-18 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (1913446..1917838)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor elt-6 Neighboring gene DENN domain type RAB GEF

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The C. elegans embryonic fate specification factor EGL-18 (GATA) is reutilized downstream of Wnt signaling to maintain a population of larval progenitor cells. Gorrepati L, et al. Worm, 2015 Jan-Mar. PMID 26430560, Free PMC Article
  2. Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein. Koh K, et al. Development, 2002 Nov. PMID 12399309
  3. ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans. Koh K, et al. Development, 2001 Aug. PMID 11532911
  4. Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1. Natarajan L, et al. Dev Biol, 2004 Aug 15. PMID 15282167
  5. Response to Tonsaker et al. Kim SK, et al. Mech Ageing Dev, 2012 Jan. PMID 22155122, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. egl-18 and elt-6 are necessary for larval seam cell specification, and for hypodermal to seam cell fate transformations induced by ectopic Wnt pathway overactivation.
    Title: C. elegans GATA factors EGL-18 and ELT-6 function downstream of Wnt signaling to maintain the progenitor fate during larval asymmetric divisions of the seam cells.
  2. egl-18/elt-6 prevent fusion and promote cell proliferation at multiple steps of vulval development
    Title: The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Putative transcription factor egl-18
NP_001294448.1
  • Confirmed by transcript evidence
NP_500143.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1913446..1917838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307519.4 → NP_001294448.1  Putative transcription factor egl-18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMB4
    Conserved Domains (1) summary
    cd00202
    Location:268 → 320
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  2. NM_067742.8 → NP_500143.1  Putative transcription factor egl-18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGF4, Q6S9C1, U4PMB4
    Conserved Domains (1) summary
    cd00202
    Location:265 → 317
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.