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tsen-54 tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176994, updated on 2-Nov-2024

Summary

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Official Symbol
tsen-54
Official Full Name
tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein
Primary source
WormBase:WBGene00018680
Locus tag
CELE_F52C12.3
See related
AllianceGenome:WB:WBGene00018680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tsen-54 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (1948191..1953317)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transcription factor elt-6 Neighboring gene DENN domain type RAB GEF Neighboring gene 18S rRNA aminocarboxypropyltransferase Neighboring gene Protein kinase domain-containing protein;non-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of tRNA-intron endonuclease complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein
NP_500146.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1948191..1953317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067745.6 → NP_500146.1  tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500146.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXV5
    Conserved Domains (1) summary
    pfam12928
    Location:28 → 63
    tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
Nucleotide Protein
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