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test-1 Thyroglobulin type-1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177010, updated on 2-Nov-2024

Summary

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Official Symbol
test-1
Official Full Name
Thyroglobulin type-1 domain-containing protein
Primary source
WormBase:WBGene00016918
Locus tag
CELE_C54E4.2
See related
AllianceGenome:WB:WBGene00016918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1); SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2); and SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See test-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (2136951..2146467)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase domain-containing protein Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Secreted protein Neighboring gene Inositol oxygenase Neighboring gene Soluble guanylate cyclase gcy-37

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Jayadev R, et al. Sci Adv, 2022 May 20. PMID 35584218, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thyroglobulin type-1 domain-containing protein
NP_001023098.1
  • Confirmed by transcript evidence
NP_001368220.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2136951..2146467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027927.6 → NP_001023098.1  Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44466
    Conserved Domains (2) summary
    cd00191
    Location:149 → 207
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16232
    Location:40 → 142
    EFh_SPARC_TICN; EF-hand, extracellular calcium-binding (EC) motif, found in testicans

  2. NM_001380084.1 → NP_001368220.1  Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PLP4
    Conserved Domains (2) summary
    cd00191
    Location:66 → 124
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cl25349
    Location:1 → 59
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
Nucleotide Protein
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