lin-1 ETS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-1
Official Full Name: ETS domain-containing protein
Primary source: WormBase:WBGene00002990
Locus tag: CELE_C37F5.1
See related: AllianceGenome:WB:WBGene00002990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in body wall musculature; non-striated muscle; reproductive system; and vulval precursor cell. Orthologous to several human genes including ELK1 (ETS transcription factor ELK1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (2275861..2300286, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling-lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM).our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants
Title: Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans.
A model is proposed in which LIN-1 recruits multiple transcriptional repressors to inhibit the 1 degrees vulval cell fate, and phosphorylation by ERK converts LIN-1 to a transcriptional activator that promotes the 1 degrees vulval cell fate.
Title: Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator.
Data show that loss-of-function mutations of moc-3 and dph-3 effectively suppress the Multivulva (Muv) phenotype of the lin-1(e1275, R175Opal) mutation.
Title: Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.
lin-39 is a direct target of the Ras pathway acting via LIN-1 and LIN-31
Title: Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39.
sumoylation of LIN-1 mediates an interaction with MEP-1 that contributes to transcriptional repression of genes that promote vulval cell fates
Title: Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
The identification of multiple mutations that reduce the function of lin-1 as an inhibitor of the primary vulval cell fate and also reduce DNA binding suggest that DNA binding is essential for LIN-1 function in Caenorhabditis.
Title: Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates.
lin-1 is required positively for the proper expression of several genes regulated by the pathway in cells adopting the 1 degrees cell fate.
Title: lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.
the interaction between LIN-1 and LET-418/Mi-2 may link RTK/Ras signaling with chromatin remodeling and gene expression
Title: The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C37F5.1 (e-PCR)
- UniSTS:319112

STS4-110 (e-PCR)
- UniSTS:242098

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ETS domain-containing protein

NP_001023051.1

Confirmed by transcript evidence

NP_001294301.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2275861..2300286 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027880.5 → NP_001023051.1 ETS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023051.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDL0

Conserved Domains (1) summary

smart00413
Location:64 → 145

ETS; erythroblast transformation specific domain
NM_001307372.2 → NP_001294301.1 ETS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294301.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PLN0

Conserved Domains (1) summary

smart00413
Location:24 → 105

ETS; erythroblast transformation specific domain