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vha-3 V-type proton ATPase 16 kDa proteolipid subunit 2/3 [ Caenorhabditis elegans ]

Gene ID: 177018, updated on 2-Nov-2024

Summary

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Official Symbol
vha-3
Official Full Name
V-type proton ATPase 16 kDa proteolipid subunit 2/3
Primary source
WormBase:WBGene00006912
Locus tag
CELE_Y38F2AL.4
See related
AllianceGenome:WB:WBGene00006912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Is expressed in excretory cell; hypodermis; and intestinal cell. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vha-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_003282.8 (2315460..2315945, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene B9 domain-containing protein 2 Neighboring gene V-type proton ATPase subunit C Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. Oka T, et al. J Biol Chem, 1998 Aug 28. PMID 9712884
  2. Promoter trapping identifies real genes in C. elegans. Hope IA, et al. Mol Gen Genet, 1998 Nov. PMID 9862485
  3. Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy. Bott LC, et al. Brain Commun, 2021. PMID 34909687, Free PMC Article
  4. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
  5. In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes. Venz R, et al. Geroscience, 2024 Apr. PMID 37644339, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
V-type proton ATPase 16 kDa proteolipid subunit 2/3
NP_001367642.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2315460..2315945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380088.1 → NP_001367642.1  V-type proton ATPase 16 kDa proteolipid subunit 2/3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0HLB3, C0HLB4, P34546, P83577
    Conserved Domains (2) summary
    TIGR01100
    Location:16 → 124
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:92 → 158
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HLB3.1
C0HLB4.1

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials