U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ilys-3 Invertebrate-type lysozyme 3 [ Caenorhabditis elegans ]

Gene ID: 177033, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ilys-3
Official Full Name
Invertebrate-type lysozyme 3
Primary source
WormBase:WBGene00016670
Locus tag
CELE_C45G7.3
See related
AllianceGenome:WB:WBGene00016670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables lysozyme activity. Involved in antibacterial innate immune response and defense response to Gram-positive bacterium. Located in late endosome lumen; lysosomal lumen; and recycling endosome lumen. Is expressed in coelomocyte; hypodermis; intestine; and terminal bulb. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ilys-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (2464456..2465443)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cadherin domain-containing protein Neighboring gene Ankyrin repeat protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Invertebrate-type lysozyme 2 Neighboring gene lysozyme

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans. Gravato-Nobre MJ, et al. PLoS Pathog, 2016 Aug. PMID 27525822, Free PMC Article
  2. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
  3. Physiological and Immunological Regulations in Caenorhabditis elegans Infected with Salmonella enterica serovar Typhi. Sivamaruthi BS, et al. Indian J Microbiol, 2014 Mar. PMID 24426167, Free PMC Article
  4. Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection. Balasubramaniam B, et al. Int J Biol Macromol, 2019 Sep 15. PMID 31252012
  5. Alterations in Caenorhabditis elegans and Cronobacter sakazakii lipopolysaccharide during interaction. Sivamaruthi BS, et al. Arch Microbiol, 2015 Mar. PMID 25416126

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we show that C. elegans invertebrate lysozyme ILYS-3 has important roles in both healthy and diseased worms; it is required to enable normal pharyngeal grinder function and to defend against bacterial pathogens
    Title: The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysozyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Invertebrate-type lysozyme 3
NP_500206.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2464456..2465443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067805.5 → NP_500206.1  Invertebrate-type lysozyme 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76357
    Conserved Domains (1) summary
    pfam05497
    Location:17 → 135
    Destabilase; Destabilase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76357.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools