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epg-9 Autophagy-related protein 101 [ Caenorhabditis elegans ]

Gene ID: 177040, updated on 2-Nov-2024

Summary

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Official Symbol
epg-9
Official Full Name
Autophagy-related protein 101
Primary source
WormBase:WBGene00022078
Locus tag
CELE_Y69A2AR.7
See related
AllianceGenome:WB:WBGene00022078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in aggrephagy. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site. Is expressed in several structures, including body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and tail. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See epg-9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (2601141..2607464)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Si:ch211-22i13.2 Neighboring gene V-SNARE coiled-coil homology domain-containing protein Neighboring gene K Homology domain-containing protein;KH domain-containing protein;Protein kinase domain-containing protein Neighboring gene PEST proteolytic signal-containing nuclear protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Zou L, et al. Acta Pharm Sin B, 2022 Oct. PMID 36213540, Free PMC Article
  2. The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy. Liang Q, et al. Autophagy, 2012 Oct. PMID 22885670
  3. The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy. Xuan Z, et al. PLoS Biol, 2023 Apr. PMID 37053235, Free PMC Article
  4. Autophagy of germ-granule components, PGL-1 and PGL-3, contributes to DNA damage-induced germ cell apoptosis in C. elegans. Min H, et al. PLoS Genet, 2019 May. PMID 31125345, Free PMC Article
  5. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Autophagy-related protein 101
NP_001023565.1
  • Confirmed by transcript evidence
NP_741338.2
  • Confirmed by transcript evidence
NP_741339.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2601141..2607464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171287.6 → NP_741338.2  Autophagy-related protein 101 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741338.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XH2
    Conserved Domains (1) summary
    pfam07855
    Location:10 → 212
    DUF1649; Protein of unknown function (DUF1649)

  2. NM_171288.5 → NP_741339.1  Autophagy-related protein 101 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0S0
    Conserved Domains (1) summary
    pfam07855
    Location:2 → 166
    DUF1649; Protein of unknown function (DUF1649)

  3. NM_001028394.5 → NP_001023565.1  Autophagy-related protein 101 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86DD3
    Conserved Domains (1) summary
    pfam07855
    Location:1 → 139
    DUF1649; Protein of unknown function (DUF1649)
Nucleotide Protein
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