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ndua-12 putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [ Caenorhabditis elegans ]

Gene ID: 177056, updated on 2-Nov-2024

Summary

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Official Symbol
ndua-12
Official Full Name
putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Primary source
WormBase:WBGene00022380
Locus tag
CELE_Y94H6A.8
See related
AllianceGenome:WB:WBGene00022380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in response to oxidative stress. Located in mitochondrion. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ndua-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (2716687..2719834, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene peptidyl-tRNA hydrolase Neighboring gene Low molecular weight phosphotyrosine protein phosphatase Neighboring gene ncRNA Neighboring gene SEP domain-containing protein;UBX domain-containing protein;UBX domain-containing protein 2 Neighboring gene DUF4781 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
  2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
NP_500247.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2716687..2719834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067846.7 → NP_500247.2  putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500247.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N2W7
    Conserved Domains (1) summary
    pfam05071
    Location:42 → 137
    NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N2W7.2

Gene LinkOut

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