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eel-1 HECT-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 177084, updated on 2-Nov-2024

Summary

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Official Symbol
eel-1
Official Full Name
HECT-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00022069
Locus tag
CELE_Y67D8C.5
See related
AllianceGenome:WB:WBGene00022069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eel-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (3032713..3050104, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Helix-loop-helix protein lin-22 Neighboring gene Protein NDNF C-terminal domain-containing protein Neighboring gene pseudo Neighboring gene Inappropriate Vulval cell Proliferation Homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans. Suthakaran N, et al. PLoS One, 2021. PMID 34797853, Free PMC Article
  2. The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Opperman KJ, et al. Cell Rep, 2017 Apr 25. PMID 28445732, Free PMC Article
  3. MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity. Xie J, et al. PLoS Genet, 2023 Sep. PMID 37729192, Free PMC Article
  4. Improved CRISPR/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans. Huang G, et al. MicroPubl Biol, 2021. PMID 34549176, Free PMC Article
  5. The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Ross AJ, et al. Cell Death Differ, 2011 Jul. PMID 21233842, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
    Title: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
  2. findings demonstrate that OGT-1 and EEL-1 form a conserved signaling complex and function together to affect GABA neuron function
    Title: A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.
  3. EEL-1 functions as the RING family ubiquitin ligase RPM-1 to regulate synapse formation and axon termination.
    Title: The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
  4. EEL-1 fine-tunes DNA damageinduced apoptosis signalling in the C. elegans germline.
    Title: The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans.
  5. EEL-1 fine tunes by 2-fold the abundance of myotactin, the putative hemidesmosome extracellular matrix receptor.
    Title: CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asymmetric protein localization involved in cell fate determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hemidesmosome assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HECT-type E3 ubiquitin transferase
NP_001294466.1
  • Partially confirmed by transcript evidence
NP_001294467.1
  • Partially confirmed by transcript evidence
NP_001294468.1
  • Partially confirmed by transcript evidence
NP_001294469.1
  • Partially confirmed by transcript evidence
NP_001294470.1
  • Partially confirmed by transcript evidence
NP_001294471.1
  • Partially confirmed by transcript evidence
NP_001294472.1
  • Partially confirmed by transcript evidence
NP_500284.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3032713..3050104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067883.5 → NP_500284.2  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500284.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GUP2
    Conserved Domains (7) summary
    smart00119
    Location:3846 → 4174
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3822 → 4175
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1440 → 1474
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 374
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:571 → 934
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2978 → 3115
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1785 → 1844
    WWE; WWE domain

  2. NM_001307542.3 → NP_001294471.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294471.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBK1
    Conserved Domains (7) summary
    smart00119
    Location:3852 → 4180
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3828 → 4181
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1440 → 1474
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 374
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:571 → 934
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2981 → 3118
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1785 → 1844
    WWE; WWE domain

  3. NM_001307538.3 → NP_001294467.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294467.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBX5
    Conserved Domains (7) summary
    smart00119
    Location:3849 → 4177
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3825 → 4178
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1440 → 1474
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 374
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:571 → 934
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2981 → 3118
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1785 → 1844
    WWE; WWE domain

  4. NM_001307540.3 → NP_001294469.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294469.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRN6
    Conserved Domains (7) summary
    smart00119
    Location:3849 → 4177
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3825 → 4178
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1440 → 1474
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 374
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:571 → 934
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2978 → 3115
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1785 → 1844
    WWE; WWE domain

  5. NM_001307537.4 → NP_001294466.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBJ5
    Conserved Domains (7) summary
    smart00119
    Location:3848 → 4176
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3824 → 4177
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1442 → 1476
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 376
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:573 → 936
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2980 → 3117
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1787 → 1846
    WWE; WWE domain

  6. NM_001307541.3 → NP_001294470.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PES6
    Conserved Domains (7) summary
    smart00119
    Location:3851 → 4179
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3827 → 4180
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1442 → 1476
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 376
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:573 → 936
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2980 → 3117
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1787 → 1846
    WWE; WWE domain

  7. NM_001307539.4 → NP_001294468.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294468.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMD1
    Conserved Domains (7) summary
    smart00119
    Location:3851 → 4179
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3827 → 4180
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1442 → 1476
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 376
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:573 → 936
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2983 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1787 → 1846
    WWE; WWE domain

  8. NM_001307543.4 → NP_001294472.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294472.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBY0
    Conserved Domains (7) summary
    smart00119
    Location:3854 → 4182
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3830 → 4183
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14306
    Location:1442 → 1476
    UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
    pfam06012
    Location:95 → 376
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:573 → 936
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2983 → 3120
    DUF4414; Domain of unknown function (DUF4414)
    cl02729
    Location:1787 → 1846
    WWE; WWE domain
Nucleotide Protein
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