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mca-3 Calcium-transporting ATPase [ Caenorhabditis elegans ]

Gene ID: 177089, updated on 2-Nov-2024

Summary

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Official Symbol
mca-3
Official Full Name
Calcium-transporting ATPase
Primary source
WormBase:WBGene00003153
Locus tag
CELE_Y67D8C.10
See related
AllianceGenome:WB:WBGene00003153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; and positive regulation of growth rate. Located in plasma membrane. Is expressed in body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mca-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (3103157..3133149, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Aminopeptidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Cytochrome P450;S10_plectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans. Bednarek EM, et al. Traffic, 2007 May. PMID 17343680
  2. Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans. Kraev A, et al. J Biol Chem, 1999 Feb 12. PMID 9933625
  3. Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference. Chen X, et al. G3 (Bethesda), 2015 Jan 9. PMID 25575561, Free PMC Article
  4. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. Silhankova M, et al. EMBO J, 2010 Dec 15. PMID 21076391, Free PMC Article
  5. Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Fares H, et al. Genetics, 2001 Sep. PMID 11560892, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data support a function for MCA-3 in the regulation of endocytosis in the C. elegans coelomocytes. In addition, they suggest that endocytosis can be blocked by high calcium levels.
    Title: The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calcium-transporting ATPase
NP_001255244.1
  • Partially confirmed by transcript evidence
NP_001294473.1
  • Partially confirmed by transcript evidence
NP_001370848.1
  • Confirmed by transcript evidence
NP_001380076.1
  • Confirmed by transcript evidence
NP_001380077.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3103157..3133149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392277.1 → NP_001380076.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76832, Q95XP6
    Conserved Domains (3) summary
    cd02081
    Location:55 → 896
    P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1
    pfam00689
    Location:849 → 1026
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam12424
    Location:1066 → 1120
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  2. NM_001383061.2 → NP_001370848.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76832, Q8MXS0
    Conserved Domains (3) summary
    cd02081
    Location:55 → 896
    P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1
    pfam00689
    Location:849 → 1026
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam12424
    Location:1066 → 1097
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  3. NM_001268315.4 → NP_001255244.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7CED8, O76832
    Conserved Domains (7) summary
    cd01427
    Location:674 → 815
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR01517
    Location:10 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:166 → 454
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:882 → 1059
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:35 → 98
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1099 → 1124
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam13246
    Location:515 → 603
    Cation_ATPase; Cation transport ATPase (P-type)

  4. NM_001392278.1 → NP_001380077.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76832, Q95XP5
    Conserved Domains (3) summary
    cd02081
    Location:55 → 896
    P-type_ATPase_Ca_PMCA-like; animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1
    pfam00689
    Location:849 → 1026
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam12424
    Location:1066 → 1108
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  5. NM_001307544.3 → NP_001294473.1  Calcium-transporting ATPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76832, U4PMD6
    Conserved Domains (6) summary
    cd01427
    Location:434 → 575
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    pfam00122
    Location:1 → 214
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:642 → 819
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00702
    Location:367 → 570
    Hydrolase; haloacid dehalogenase-like hydrolase
    pfam12424
    Location:859 → 901
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam13246
    Location:275 → 363
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein
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