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siah-1 E3 ubiquitin-protein ligase siah-1 [ Caenorhabditis elegans ]

Gene ID: 177138, updated on 2-Nov-2024

Summary

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Official Symbol
siah-1
Official Full Name
E3 ubiquitin-protein ligase siah-1
Primary source
WormBase:WBGene00021369
Locus tag
CELE_Y37E11AR.2
See related
AllianceGenome:WB:WBGene00021369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in programmed cell death involved in cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to several human genes including SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See siah-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (3744048..3747351)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 Neighboring gene ncRNA Neighboring gene glucuronosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Kim H, et al. Mol Cell, 2011 Nov 18. PMID 22099302, Free PMC Article
  2. HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. Kinet MJ, et al. Elife, 2016 Mar 8. PMID 26952214, Free PMC Article
  3. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
  4. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Couillault C, et al. Nat Immunol, 2004 May. PMID 15048112
  5. Functional importance of an inverted formin C-terminal tail at morphologically dynamic epithelial junctions. Hegsted A, et al. Cytoskeleton (Hoboken), 2019 Apr. PMID 31215743, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in programmed cell death involved in cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase siah-1
NP_500409.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3744048..3747351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068008.6 → NP_500409.1  E3 ubiquitin-protein ligase siah-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46223, Q965X6
    Conserved Domains (2) summary
    cd00162
    Location:155 → 194
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam03145
    Location:197 → 396
    Sina; Seven in absentia protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965X6.3

Gene LinkOut

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