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vab-2 Ephrin RBD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177140, updated on 2-Nov-2024

Summary

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Official Symbol
vab-2
Official Full Name
Ephrin RBD domain-containing protein
Primary source
WormBase:WBGene00006869
Locus tag
CELE_Y37E11AR.6
See related
AllianceGenome:WB:WBGene00006869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and epidermis morphogenesis. Located in axon and external side of plasma membrane. Is expressed in several structures, including anterior ganglion; neuroblasts; neurons; somatic nervous system; and ventral ganglion (post). Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Orthologous to human EFNB1 (ephrin B1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vab-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (3761195..3766826, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene Bestrophin homolog Neighboring gene Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans. Torpe N, et al. Genetics, 2017 Jan. PMID 27821431, Free PMC Article
  2. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Wu Z, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17848506, Free PMC Article
  3. Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans. Grossman EN, et al. Genetics, 2013 Nov. PMID 23979582, Free PMC Article
  4. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Chin-Sang ID, et al. Cell, 1999 Dec 23. PMID 10619431
  5. Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1. Tucker M, et al. Dev Biol, 2008 Jun 15. PMID 18452914, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ephrin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ephrin RBD domain-containing protein
NP_001294296.1
  • Confirmed by transcript evidence
NP_500412.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3761195..3766826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068011.4 → NP_500412.1  Ephrin RBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEE7
    Conserved Domains (1) summary
    cd02675
    Location:25 → 153
    Ephrin_ectodomain; Ectodomain of Ephrins

  2. NM_001307367.3 → NP_001294296.1  Ephrin RBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PQX3
    Conserved Domains (1) summary
    cl19115
    Location:1 → 48
    Cupredoxin; Cupredoxin superfamily
Nucleotide Protein
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