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bris-1 SEC7 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177142, updated on 2-Nov-2024

Summary

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Official Symbol
bris-1
Official Full Name
SEC7 domain-containing protein
Primary source
WormBase:WBGene00019726
Locus tag
CELE_M02B7.5
See related
AllianceGenome:WB:WBGene00019726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is expressed in hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1); IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); and IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bris-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (3807870..3819328, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FTH domain-containing protein Neighboring gene ncRNA Neighboring gene DUF1014-domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity. Chen D, et al. J Cell Biol, 2018 Jun 4. PMID 29563216, Free PMC Article
  2. Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans. Teuliere J, et al. Genetics, 2014 Sep. PMID 25053664, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SEC7 domain-containing protein
NP_001294288.1
  • Confirmed by transcript evidence
NP_001368213.1
  • Confirmed by transcript evidence
NP_001368214.1
  • Confirmed by transcript evidence
NP_500420.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3807870..3819328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068019.6 → NP_500420.3  SEC7 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500420.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94287
    Conserved Domains (2) summary
    cd13318
    Location:445 → 573
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:224 → 417
    Sec7; Sec7 domain

  2. NM_001307359.4 → NP_001294288.1  SEC7 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294288.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PAR9
    Conserved Domains (2) summary
    cd13318
    Location:366 → 494
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:145 → 338
    Sec7; Sec7 domain

  3. NM_001380166.1 → NP_001368213.1  SEC7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB66
    Conserved Domains (2) summary
    cd00171
    Location:86 → 279
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam16453
    Location:300 → 435
    IQ_SEC7_PH; PH domain

  4. NM_001380167.2 → NP_001368214.1  SEC7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PLL0
    Conserved Domains (2) summary
    cd00171
    Location:81 → 274
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam16453
    Location:295 → 430
    IQ_SEC7_PH; PH domain
Nucleotide Protein
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