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ell-1 OCEL domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177206, updated on 2-Nov-2024

Summary

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Official Symbol
ell-1
Official Full Name
OCEL domain-containing protein
Primary source
WormBase:WBGene00021281
Locus tag
CELE_Y24D9A.1
See related
AllianceGenome:WB:WBGene00021281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II and snRNA transcription by RNA polymerase II. Located in nucleus. Is expressed in hypodermis; intestine; pharynx; tail; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2) and ELL (elongation factor for RNA polymerase II). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ell-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (4394410..4415621)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL8 Neighboring gene SET domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Seven TM Receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. Cai L, et al. J Biol Chem, 2011 Oct 14. PMID 21880729, Free PMC Article
  2. Caenorhabditis elegans AF4/FMR2 Family Homolog affl-2 Regulates Heat-Shock-Induced Gene Expression. Walton SJ, et al. Genetics, 2020 Aug. PMID 32518061, Free PMC Article
  3. Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells. Cai L, et al. Biochem Biophys Res Commun, 2014 May 2. PMID 24727455, Free PMC Article
  4. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.
    Title: Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription elongation factor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
OCEL domain-containing protein
NP_001299985.1
  • Confirmed by transcript evidence
NP_001379985.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4394410..4415621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392296.1 → NP_001379985.1  OCEL domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N554
    Conserved Domains (2) summary
    pfam07303
    Location:560 → 669
    Occludin_ELL; Occludin homology domain
    pfam10390
    Location:86 → 359
    ELL; RNA polymerase II elongation factor ELL

  2. NM_001313056.3 → NP_001299985.1  OCEL domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARM3
    Conserved Domains (1) summary
    pfam07303
    Location:180 → 289
    Occludin_ELL; Occludin homology domain

RNA

  1. NR_132459.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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