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wapl-1 WAPL domain-containing protein;Wings apart-like protein homolog 1 [ Caenorhabditis elegans ]

Gene ID: 177211, updated on 2-Nov-2024

Summary

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Official Symbol
wapl-1
Official Full Name
WAPL domain-containing protein;Wings apart-like protein homolog 1
Primary source
WormBase:WBGene00019953
Locus tag
CELE_R08C7.10
See related
AllianceGenome:WB:WBGene00019953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cohesin unloader activity. Involved in positive regulation of double-strand break repair via homologous recombination. Located in germ cell nucleus. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wapl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (4442362..4445740, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Histone H2A.V Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CDC50 family protein chat-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes. Crawley O, et al. Elife, 2016 Feb 4. PMID 26841696, Free PMC Article
  2. cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis. Stanvitch G, et al. Genetics, 2008 Jan. PMID 18202360, Free PMC Article
  3. The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1. Castellano-Pozo M, et al. Elife, 2023 Aug 31. PMID 37650378, Free PMC Article
  4. Condensin I protects meiotic cohesin from WAPL-1 mediated removal. Hernandez MR, et al. PLoS Genet, 2018 May. PMID 29768402, Free PMC Article
  5. Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in Caenorhabditis elegans. Mohammad A, et al. Genetics, 2018 Aug. PMID 29941619, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
    Title: The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
  2. Data show that condensin I binds to WAPL-1 and counteracts WAPL-1-dependent cohesin removal.
    Title: Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
  3. WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion.
    Title: Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP-dependent protein-DNA unloader activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cohesin unloader activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WAPL domain-containing protein;Wings apart-like protein homolog 1
NP_001360111.1
  • Confirmed by transcript evidence
NP_001368333.1
  • Confirmed by transcript evidence
NP_001368334.1
  • Confirmed by transcript evidence
NP_500566.1
  • Confirmed by transcript evidence
NP_500567.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4442362..4445740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068165.6 → NP_500566.1  Wings apart-like protein homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500566.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0H5
    Conserved Domains (1) summary
    pfam07814
    Location:217 → 561
    WAPL; Wings apart-like protein regulation of heterochromatin

  2. NM_068166.8 → NP_500567.1  WAPL domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21843
    Conserved Domains (1) summary
    pfam07814
    Location:215 → 559
    WAPL; Wings apart-like protein regulation of heterochromatin

  3. NM_001372798.2 → NP_001360111.1  WAPL domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0H6
    Conserved Domains (1) summary
    pfam07814
    Location:215 → 559
    WAPL; Wings apart-like protein regulation of heterochromatin

  4. NM_001380189.1 → NP_001368334.1  WAPL domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PCH6
    Conserved Domains (1) summary
    cl00304
    Location:18 → 95
    TP_methylase; S-AdoMet-dependent tetrapyrrole methylases

  5. NM_001380190.1 → NP_001368333.1  WAPL domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PC40
    Conserved Domains (1) summary
    pfam07814
    Location:217 → 561
    WAPL; Wings apart-like protein regulation of heterochromatin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2L0H5.1

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