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chat-1 CDC50 family protein chat-1 [ Caenorhabditis elegans ]

Gene ID: 177213, updated on 2-Nov-2024

Summary

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Official Symbol
chat-1
Official Full Name
CDC50 family protein chat-1
Primary source
WormBase:WBGene00019946
Locus tag
CELE_R08C7.2
See related
AllianceGenome:WB:WBGene00019946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including intestine. Orthologous to several human genes including TMEM30A (transmembrane protein 30A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See chat-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (4447331..4449897)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WAPL domain-containing protein;Wings apart-like protein homolog 1 Neighboring gene Histone H2A.V Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Flocculation protein FLO11-like Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1. Chen B, et al. PLoS Genet, 2010 Dec 9. PMID 21170358, Free PMC Article
  2. Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants. Li X, et al. Mol Biol Cell, 2013 Apr. PMID 23427264, Free PMC Article
  3. Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry. Beer KB, et al. Proc Natl Acad Sci U S A, 2018 Feb 6. PMID 29367422, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHAT-1 and TAT-1 maintain membrane phosphatidylserine asymmetry, thus promoting membrane tubulation and regulating endocytic sorting and recycling.
    Title: Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDC50 family protein chat-1
NP_001023332.1
  • Confirmed by transcript evidence
NP_001040979.1
  • Confirmed by transcript evidence
NP_001368332.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4447331..4449897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028161.4 → NP_001023332.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023332.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0H3, H2L0H4, Q2L6W0, U4PMW1
    Conserved Domains (1) summary
    pfam03381
    Location:72 → 333
    CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

  2. NM_001047514.4 → NP_001040979.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0H3
    Conserved Domains (1) summary
    pfam03381
    Location:53 → 152
    CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

  3. NM_001380191.1 → NP_001368332.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam03381
    Location:1 → 91
    CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

RNA

  1. NR_138505.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2L0H3.1

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