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jmjd-1.2 JmjC domain-containing protein;Lysine-specific demethylase 7 homolog [ Caenorhabditis elegans ]

Gene ID: 177232, updated on 2-Nov-2024

Summary

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Official Symbol
jmjd-1.2
Official Full Name
JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
Primary source
WormBase:WBGene00017920
Locus tag
CELE_F29B9.2
See related
AllianceGenome:WB:WBGene00017920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Is expressed in several structures, including germ cell; hypodermis; intestine; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma and syndromic X-linked intellectual disability Siderius type. Orthologous to several human genes including KDM7A (lysine demethylase 7A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See jmjd-1.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (4660991..4665212)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial Ribosomal Protein, Small Neighboring gene Cytochrome c oxidase polypeptide VIIc Neighboring gene Protein-lysine N-methyltransferase CELE_F29B9.1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress. Myers TR, et al. Sci Rep, 2018 Feb 28. PMID 29491442, Free PMC Article
  2. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Yang Y, et al. Cell Res, 2010 Aug. PMID 20567261
  3. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Lin H, et al. Cell Res, 2010 Aug. PMID 20567262
  4. Identification of family determining residues in Jumonji-C lysine demethylases: A sequence-based, family wide classification. Slama P. Proteins, 2016 Mar. PMID 26757344, Free PMC Article
  5. JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling. Riveiro AR, et al. Development, 2017 Mar 1. PMID 28126843

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a role for jmjd-1.2 in the maintenance of genome integrity after replication stress
    Title: JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.
  2. jmjd-1.2 has a role in axon guidance that might be relevant for the onset of X-linked mental retardation
    Title: JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling.
  3. Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling.
    Title: Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K27me2/H3K27me3 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27me2/H3K27me3 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
NP_001294381.1
  • Confirmed by transcript evidence
NP_500610.1
  • Confirmed by transcript evidence
NP_500611.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4660991..4665212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068209.7 → NP_500610.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500610.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9BI67, Q9GYI0
    Conserved Domains (2) summary
    cd15517
    Location:211 → 287
    PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
    cl21464
    Location:495 → 595
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_068210.5 → NP_500611.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GYI0
    Conserved Domains (2) summary
    cd15517
    Location:198 → 274
    PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
    cl21464
    Location:482 → 582
    cupin_like; Conserved domain found in cupin and related proteins

  3. NM_001307452.3 → NP_001294381.1  JmjC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294381.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB84
    Conserved Domains (3) summary
    cd15517
    Location:230 → 306
    PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
    pfam17811
    Location:619 → 705
    JHD; Jumonji helical domain
    cl21464
    Location:514 → 614
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GYI0.1

Gene LinkOut

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