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miro-1 Mitochondrial Rho GTPase 1 [ Caenorhabditis elegans ]

Gene ID: 177238, updated on 2-Nov-2024

Summary

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Official Symbol
miro-1
Official Full Name
Mitochondrial Rho GTPase 1
Primary source
WormBase:WBGene00019544
Locus tag
CELE_K08F11.5
See related
AllianceGenome:WB:WBGene00019544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in body wall muscle cell; intestine; neurons; and pharynx. Orthologous to human RHOT1 (ras homolog family member T1) and RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See miro-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (4712825..4715807, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene COP9/Signalosome and eIF3 complex-shared subunit 1 Neighboring gene Tyrosine--tRNA ligase Neighboring gene Lipoprotein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span. Shen Y, et al. PLoS One, 2016. PMID 27064409, Free PMC Article
  2. Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport. Wu Y, et al. J Cell Biol, 2024 May 6. PMID 38470363, Free PMC Article
  3. MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans. Ren X, et al. EMBO Rep, 2023 Aug 3. PMID 37306041, Free PMC Article
  4. Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling. Fu H, et al. Nat Commun, 2020 Feb 26. PMID 32103012, Free PMC Article
  5. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Mao K, et al. Cell Metab, 2019 May 7. PMID 30799287, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
    Title: MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
  2. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca(2+). The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function.
    Title: Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling.
  3. miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.
    Title: C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial outer membrane permeabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial Rho GTPase 1
NP_500620.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4712825..4715807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068219.4 → NP_500620.1  Mitochondrial Rho GTPase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94263
    Conserved Domains (6) summary
    cd01892
    Location:423 → 592
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:9 → 173
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:425 → 608
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam00071
    Location:11 → 171
    Ras; Ras family
    pfam08355
    Location:352 → 417
    EF_assoc_1; EF hand associated
    pfam08356
    Location:225 → 306
    EF_assoc_2; EF hand associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94263.1

Gene LinkOut

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