lam-1 Laminin subunit beta-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lam-1
Official Full Name: Laminin subunit beta-1
Primary source: WormBase:WBGene00002247
Locus tag: CELE_W03F8.5
See related: AllianceGenome:WB:WBGene00002247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in pharynx development and positive regulation of locomotion. Located in basement membrane. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Pierson syndrome; amelogenesis imperfecta type 1A; autistic disorder; lissencephaly 5; and nephrotic syndrome type 5. Orthologous to several human genes including LAMB1 (laminin subunit beta 1) and LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lam-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (5173332..5183746)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W03F8.5 (e-PCR)
- UniSTS:311114

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Laminin subunit beta-1

NP_001368376.1

Confirmed by transcript evidence

NP_500734.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5173332..5183746

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068333.6 → NP_500734.3 Laminin subunit beta-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500734.3

Status: REVIEWED

UniProtKB/TrEMBL

O44565

Conserved Domains (6) summary

smart00136
Location:31 → 273

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:779 → 824

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:1088 → 1144

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:827 → 876

Laminin_EGF; Laminin EGF domain

cl12013
Location:1197 → 1327

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19854
Location:1448 → 1565

DUF1002; Protein of unknown function (DUF1002)
NM_001380214.1 → NP_001368376.1 Laminin subunit beta-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIX7

Conserved Domains (1) summary

cl40438
Location:8 → 75

cc_LAMB_C; C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family