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tni-4 Troponin I 4 [ Caenorhabditis elegans ]

Gene ID: 177295, updated on 2-Nov-2024

Summary

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Official Symbol
tni-4
Official Full Name
Troponin I 4
Primary source
WormBase:WBGene00006586
Locus tag
CELE_W03F8.1
See related
AllianceGenome:WB:WBGene00006586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables troponin C binding activity. Involved in embryo development and nematode pharyngeal pumping. Located in sarcomere. Is expressed in pharynx. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tni-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (5204591..5207124)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
  2. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
  3. Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system. Ono K, et al. Mol Biol Cell, 2004 Jun. PMID 15064356, Free PMC Article
  4. Conservation of mRNA and protein expression during development of C. elegans. Grün D, et al. Cell Rep, 2014 Feb 13. PMID 24462290
  5. Cell-specific proteomic analysis in Caenorhabditis elegans. Yuet KP, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691744, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables troponin C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Troponin I 4
NP_500741.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5204591..5207124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068340.7 → NP_500741.2  Troponin I 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500741.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44572, Q5FBV3
    Conserved Domains (1) summary
    pfam00992
    Location:45 → 172
    Troponin; Troponin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44572.2

Gene LinkOut

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