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hda-6 Histone deacetylase 6;UBP-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177316, updated on 2-Nov-2024

Summary

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Official Symbol
hda-6
Official Full Name
Histone deacetylase 6;UBP-type domain-containing protein
Primary source
WormBase:WBGene00018319
Locus tag
CELE_F41H10.6
See related
AllianceGenome:WB:WBGene00018319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hda-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (5356543..5364306, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WH2 domain-containing protein Neighboring gene ncRNA Neighboring gene TLC domain-containing protein Neighboring gene ncRNA Neighboring gene GRIP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans. Xu A, et al. Aging Cell, 2019 Apr. PMID 30638295, Free PMC Article
  2. The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. Warburton-Pitt SR, et al. PLoS Genet, 2014 Dec. PMID 25501555, Free PMC Article
  3. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. Bates EA, et al. J Neurosci, 2006 Mar 8. PMID 16525063, Free PMC Article
  4. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Yu R, et al. Nat Commun, 2021 Mar 31. PMID 33790287, Free PMC Article
  5. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein lysine deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone deacetylase 6;UBP-type domain-containing protein
NP_001122780.1
  • Confirmed by transcript evidence
NP_001255270.1
  • Confirmed by transcript evidence
NP_500787.1
  • Confirmed by transcript evidence
NP_500788.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5356543..5364306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129308.4 → NP_001122780.1  UBP-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPD8
    Conserved Domains (2) summary
    pfam02148
    Location:877 → 939
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:440 → 795
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. NM_068386.5 → NP_500787.1  Histone deacetylase 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500787.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20296, Q9BI90, Q9BI91
    Conserved Domains (2) summary
    pfam02148
    Location:875 → 937
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:438 → 793
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  3. NM_001268341.3 → NP_001255270.1  UBP-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JYB7
    Conserved Domains (1) summary
    pfam02148
    Location:58 → 120
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  4. NM_068387.5 → NP_500788.1  Histone deacetylase 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500788.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20296
    Conserved Domains (1) summary
    cl17011
    Location:438 → 793
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20296.2

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