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elo-6 Long chain fatty acid elongase 6 [ Caenorhabditis elegans ]

Gene ID: 177321, updated on 2-Nov-2024

Summary

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Official Symbol
elo-6
Official Full Name
Long chain fatty acid elongase 6
Primary source
WormBase:WBGene00001244
Locus tag
CELE_F41H10.8
See related
AllianceGenome:WB:WBGene00001244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty acid elongase activity. Involved in methyl-branched fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in amphid neurons; intestine; nerve ring; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See elo-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (5386629..5388559, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CACTA en-spm transposon protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HORMA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment. Cao X, et al. Cell Mol Life Sci, 2023 Jul 14. PMID 37450052, Free PMC Article
  2. Monomethyl branched-chain fatty acids are critical for Caenorhabitis elegans survival in elevated glucose conditions. Vieira AFC, et al. J Biol Chem, 2022 Feb. PMID 34826420, Free PMC Article
  3. Modulation of Neurotransmitter Pathways and Associated Metabolites by Systemic Silencing of Gut Genes in C. elegans. Shukla S, et al. Diagnostics (Basel), 2023 Jul 10. PMID 37510066, Free PMC Article
  4. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Pauli F, et al. Development, 2006 Jan. PMID 16354718, Free PMC Article
  5. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. elo-5 and elo-6 may be transcriptional targets of LPD-1
    Title: Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methyl-branched fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Long chain fatty acid elongase 6
NP_500797.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5386629..5388559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068396.8 → NP_500797.1  Long chain fatty acid elongase 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500797.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20303
    Conserved Domains (1) summary
    pfam01151
    Location:33 → 262
    ELO; GNS1/SUR4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20303.1

Gene LinkOut

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