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mgl-3 G-protein coupled receptors family 3 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177327, updated on 2-Nov-2024

Summary

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Official Symbol
mgl-3
Official Full Name
G-protein coupled receptors family 3 profile domain-containing protein
Primary source
WormBase:WBGene00021152
Locus tag
CELE_Y4C6A.2
See related
AllianceGenome:WB:WBGene00021152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in NSM; head neurons; and nerve ring. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; congenital stationary night blindness 1B; and schizophrenia. Orthologous to several human genes including GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mgl-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
18
Sequence:
Chromosome: IV; NC_003282.8 (5439005..5450802)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabotropic Glutamate Receptors: MODULATORS OF CONTEXT-DEPENDENT FEEDING BEHAVIOUR IN C. ELEGANS. Dillon J, et al. J Biol Chem, 2015 Jun 12. PMID 25869139, Free PMC Article
  2. Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans. Dillon J, et al. Biochem Soc Trans, 2006 Nov. PMID 17052233
  3. Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans. Sadananda G, et al. Neurosci Lett, 2021 Feb 16. PMID 33493646
  4. Obesogenic effect of erythromycin on Caenorhabditis elegans through over-eating and lipid metabolism disturbances. Luo Z, et al. Environ Pollut, 2022 Feb 1. PMID 34863891
  5. Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line. Yeon J, et al. G3 (Bethesda), 2023 Sep 30. PMID 37572357, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 3 profile domain-containing protein
NP_001076735.3
  • Partially confirmed by transcript evidence
NP_001299986.1
  • Partially confirmed by transcript evidence
NP_001299987.1
  • Partially confirmed by transcript evidence
NP_001299988.1
  • Partially confirmed by transcript evidence
NP_001299989.1
  • Partially confirmed by transcript evidence
NP_741400.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5439005..5450802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083266.5 → NP_001076735.3  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076735.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1IMB8
    Conserved Domains (3) summary
    cd15934
    Location:577 → 825
    7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:507 → 556
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:41 → 493
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  2. NM_171341.5 → NP_741400.2  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741400.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXU2
    Conserved Domains (3) summary
    cd15934
    Location:577 → 825
    7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:507 → 556
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:41 → 493
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  3. NM_001313057.3 → NP_001299986.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV56
    Conserved Domains (3) summary
    cd15934
    Location:167 → 415
    7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:97 → 146
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:2 → 79
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  4. NM_001313058.3 → NP_001299987.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXG3
    Conserved Domains (3) summary
    cd15934
    Location:167 → 415
    7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:97 → 146
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:2 → 79
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  5. NM_001313059.3 → NP_001299988.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS42
    Conserved Domains (2) summary
    cd14964
    Location:5 → 26
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1 → 217
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. NM_001313060.3 → NP_001299989.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUI1
    Conserved Domains (2) summary
    cd14964
    Location:5 → 26
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1 → 217
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_132461.1 RNA Sequence

    Status: REVIEWED

  2. NR_132462.1 RNA Sequence

    Status: REVIEWED

  3. NR_132463.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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