U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fkh-7 Fork-head domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177340, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
fkh-7
Official Full Name
Fork-head domain-containing protein
Primary source
WormBase:WBGene00001439
Locus tag
CELE_F26D12.1
See related
AllianceGenome:WB:WBGene00001439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; autism spectrum disorder (multiple); autoimmune disease (multiple); communication disorder (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See fkh-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (5584684..5610378)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714
  2. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Panowski SH, et al. Nature, 2007 May 31. PMID 17476212
  3. The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. McGhee JD, et al. Dev Biol, 2007 Feb 15. PMID 17113066
  4. The regulatory content of intergenic DNA shapes genome architecture. Nelson CE, et al. Genome Biol, 2004. PMID 15059258, Free PMC Article
  5. Individual cell types in C. elegans age differently and activate distinct cell-protective responses. Roux AE, et al. Cell Rep, 2023 Aug 29. PMID 37531250

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Fork-head domain-containing protein
NP_001023147.1
  • Partially confirmed by transcript evidence
NP_001023148.1
  • Partially confirmed by transcript evidence
NP_001293720.1
  • Confirmed by transcript evidence
NP_001293721.1
  • Confirmed by transcript evidence
NP_001293723.1
  • Confirmed by transcript evidence
NP_001293724.1
  • Confirmed by transcript evidence
NP_001293811.1
  • Partially confirmed by transcript evidence
NP_001293812.1
  • Partially confirmed by transcript evidence
NP_001293813.1
  • Confirmed by transcript evidence
NP_001293814.1
  • Confirmed by transcript evidence
NP_001293815.1
  • Confirmed by transcript evidence
NP_001293816.1
  • Confirmed by transcript evidence
NP_001368377.1
  • Confirmed by transcript evidence
NP_001368378.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5584684..5610378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306884.4 → NP_001293813.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLS2
    Conserved Domains (2) summary
    cd20065
    Location:562 → 644
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:326 → 393
    FOXP-CC; FOXP coiled-coil domain

  2. NM_001306882.4 → NP_001293811.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293811.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLX2
    Conserved Domains (2) summary
    cd20065
    Location:562 → 644
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:326 → 393
    FOXP-CC; FOXP coiled-coil domain

  3. NM_001027976.7 → NP_001023147.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86MF0
    Conserved Domains (3) summary
    COG5025
    Location:515 → 676
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00059
    Location:563 → 636
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:326 → 393
    FOXP-CC; FOXP coiled-coil domain

  4. NM_001306885.3 → NP_001293814.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJE7
    Conserved Domains (2) summary
    cd20065
    Location:562 → 644
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:326 → 393
    FOXP-CC; FOXP coiled-coil domain

  5. NM_001027977.5 → NP_001023148.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023148.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86ME9
    Conserved Domains (3) summary
    COG5025
    Location:329 → 490
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd00059
    Location:377 → 450
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:140 → 207
    FOXP-CC; FOXP coiled-coil domain

  6. NM_001306883.3 → NP_001293812.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLW4
    Conserved Domains (2) summary
    cd20065
    Location:376 → 458
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:140 → 207
    FOXP-CC; FOXP coiled-coil domain

  7. NM_001306886.3 → NP_001293815.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CKK8
    Conserved Domains (2) summary
    cd20065
    Location:376 → 458
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:140 → 207
    FOXP-CC; FOXP coiled-coil domain

  8. NM_001306887.3 → NP_001293816.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293816.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLX8
    Conserved Domains (2) summary
    cd20065
    Location:376 → 458
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
    pfam16159
    Location:140 → 207
    FOXP-CC; FOXP coiled-coil domain

  9. NM_001306791.3 → NP_001293720.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293720.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIY1
    Conserved Domains (2) summary
    COG5025
    Location:32 → 284
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20065
    Location:79 → 161
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  10. NM_001380234.1 → NP_001368377.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLH2
    Conserved Domains (1) summary
    cd20065
    Location:79 → 161
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  11. NM_001306794.3 → NP_001293723.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293723.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLF5
    Conserved Domains (1) summary
    cd20065
    Location:79 → 161
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  12. NM_001306795.3 → NP_001293724.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLC1
    Conserved Domains (1) summary
    cd20065
    Location:79 → 161
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  13. NM_001306792.3 → NP_001293721.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293721.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK27

  14. NM_001380235.1 → NP_001368378.1  Fork-head domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CIY6

RNA

  1. NR_131492.1 RNA Sequence

    Status: REVIEWED

  2. NR_131493.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous