sams-3 putative S-adenosylmethionine synthase 3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: sams-3
Official Full Name: putative S-adenosylmethionine synthase 3
Primary source: WormBase:WBGene00015538
Locus tag: CELE_C06E7.1
See related: AllianceGenome:WB:WBGene00015538
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including enteric muscle; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See sams-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (5848657..5850843)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C06E7.1 (e-PCR)
- UniSTS:306117

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: putative S-adenosylmethionine synthase 3

NP_500872.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5848657..5850843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068471.8 → NP_500872.1 putative S-adenosylmethionine synthase 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500872.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P50305

Conserved Domains (4) summary

PTZ00104
Location:1 → 388

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:5 → 102

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:117 → 238

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

pfam02773
Location:240 → 376

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain