mcu-1 Calcium uniporter protein, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mcu-1
Official Full Name: Calcium uniporter protein, mitochondrial
Primary source: WormBase:WBGene00019296
Locus tag: CELE_K02B2.3
See related: AllianceGenome:WB:WBGene00019296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium channel activity and identical protein binding activity. Involved in several processes, including calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein homooligomerization. Predicted to be located in mitochondrial inner membrane. Predicted to be part of uniplex complex. Orthologous to several human genes including MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mcu-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (5937447..5939230, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state.
Title: The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state.
Mitochondrial Ca(2+) Dynamics in MCU Knockout C. elegans Worms.
Title: Mitochondrial Ca(2+) Dynamics in MCU Knockout C. elegans Worms.
Mn2+ binds specifically to the MCU protein DXXE motif, which can be displaced by Ca2+.
Title: Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02B2.3 (e-PCR)
- UniSTS:311357

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables uniporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Calcium uniporter protein, mitochondrial

NP_500892.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5937447..5939230 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068491.7 → NP_500892.1 Calcium uniporter protein, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21121

Conserved Domains (1) summary

pfam04678
Location:93 → 299

MCU; Mitochondrial calcium uniporter