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cpi-1 Cystatin cpi-1 [ Caenorhabditis elegans ]

Gene ID: 177372, updated on 2-Nov-2024

Summary

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Official Symbol
cpi-1
Official Full Name
Cystatin cpi-1
Primary source
WormBase:WBGene00000535
Locus tag
CELE_K08B4.6
See related
AllianceGenome:WB:WBGene00000535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy; age related macular degeneration 11; and ectodermal dysplasia 15. Orthologous to several human genes including CST3 (cystatin C); CST4 (cystatin S); and CST1 (cystatin SN). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cpi-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (6092603..6093680, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cystatin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Suppressor of hairless protein homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parasite-specific immunomodulatory functions of filarial cystatin. Schierack P, et al. Infect Immun, 2003 May. PMID 12704112, Free PMC Article
  2. Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins. Phiri AM, et al. Parasitology, 2014 Feb. PMID 24001183
  3. Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. Gregory WF, et al. Int J Biochem Cell Biol, 2008. PMID 18249028
  4. Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Murray J, et al. Mol Biochem Parasitol, 2005 Feb. PMID 15664654
  5. Gene expression profiling studies on Caenorhabditis elegans dystrophin mutants dys-1(cx-35) and dys-1(cx18). Towers PR, et al. Genomics, 2006 Nov. PMID 16962739

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wild-type Caenorhabditis elegans deploy cystatins CPI-1 and CPI-2 to resist cysteine proteinase (CP) attack.
    Title: Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cystatin cpi-1
NP_500915.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6092603..6093680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068514.6 → NP_500915.1  Cystatin cpi-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDZ9
    Conserved Domains (1) summary
    smart00043
    Location:20 → 124
    CY; Cystatin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EDZ9.1

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