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unc-77 Ion transport domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177379, updated on 2-Nov-2024

Summary

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Official Symbol
unc-77
Official Full Name
Ion transport domain-containing protein
Primary source
WormBase:WBGene00006809
Locus tag
CELE_C11D2.6
See related
AllianceGenome:WB:WBGene00006809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Is expressed in intestine and nervous system. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-77 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
31
Sequence:
Chromosome: IV; NC_003282.8 (6157306..6183857, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BLOC-1-related complex subunit 5 Neighboring gene PUA domain-containing protein Neighboring gene Queuosine 5'-phosphate N-glycosylase/hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pre-microRNA mir-8202 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Gain-of-Function Mutation in NALCN in a Child with Intellectual Disability, Ataxia, and Arthrogryposis. Aoyagi K, et al. Hum Mutat, 2015 Aug. PMID 25864427
  2. NALCN Channels Are Not Major targets of Gα (o) or Gα (q) Modulation in the C. elegans Egg-Laying Behavior Circuit. Jose A, et al. MicroPubl Biol, 2024. PMID 38287929, Free PMC Article
  3. Corrigendum. . Genetics, 2017 Aug. PMID 28778879, Free PMC Article
  4. The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans. Hoyt JM, et al. G3 (Bethesda), 2017 Sep 7. PMID 28696924, Free PMC Article
  5. De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia. Fukai R, et al. J Hum Genet, 2016 May. PMID 26763878

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCA-1 and UNC-80 regulate neuronal activity at least in part by transmitting depolarization signals to synapses in C. elegans neurons.
    Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
  2. UNC-80 is required for the proper localization of the NCA-1 and NCA-2 ion channel subunits.
    Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, cholinergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ion transport domain-containing protein
NP_001293818.1
  • Confirmed by transcript evidence
NP_001293819.1
  • Confirmed by transcript evidence
NP_001293820.1
  • Confirmed by transcript evidence
NP_001293821.1
  • Confirmed by transcript evidence
NP_001293822.1
  • Confirmed by transcript evidence
NP_001293823.1
  • Confirmed by transcript evidence
NP_001293824.1
  • Partially confirmed by transcript evidence
NP_001293825.1
  • Partially confirmed by transcript evidence
NP_001293826.1
  • Partially confirmed by transcript evidence
NP_001293827.1
  • Partially confirmed by transcript evidence
NP_001294631.1
  • Confirmed by transcript evidence
NP_001294632.1
  • Confirmed by transcript evidence
NP_500926.3
  • Confirmed by transcript evidence
NP_500927.3
  • Confirmed by transcript evidence
NP_741413.2
  • Confirmed by transcript evidence
NP_741414.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6157306..6183857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068525.4 → NP_500926.3  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500926.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, Q688B4
    Conserved Domains (1) summary
    pfam00520
    Location:449 → 654
    Ion_trans; Ion transport protein

  2. NM_171353.6 → NP_741414.2  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741414.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, Q8MXH5
    Conserved Domains (1) summary
    pfam00520
    Location:389 → 594
    Ion_trans; Ion transport protein

  3. NM_001307702.3 → NP_001294631.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294631.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, U4PCH9
    Conserved Domains (1) summary
    pfam00520
    Location:449 → 654
    Ion_trans; Ion transport protein

  4. NM_001306896.3 → NP_001293825.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, V6CLZ1
    Conserved Domains (1) summary
    pfam00520
    Location:434 → 660
    Ion_trans; Ion transport protein

  5. NM_001306897.3 → NP_001293826.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293826.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, V6CLY6
    Conserved Domains (1) summary
    pfam00520
    Location:434 → 660
    Ion_trans; Ion transport protein

  6. NM_001306898.3 → NP_001293827.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CLU1
    Conserved Domains (1) summary
    pfam00520
    Location:434 → 660
    Ion_trans; Ion transport protein

  7. NM_001306895.3 → NP_001293824.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293824.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CKM5
    Conserved Domains (1) summary
    pfam00520
    Location:434 → 660
    Ion_trans; Ion transport protein

  8. NM_001306892.3 → NP_001293821.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, V6CLY1
    Conserved Domains (1) summary
    pfam00520
    Location:416 → 642
    Ion_trans; Ion transport protein

  9. NM_001306893.3 → NP_001293822.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, V6CLT6
    Conserved Domains (1) summary
    pfam00520
    Location:416 → 642
    Ion_trans; Ion transport protein

  10. NM_001306894.3 → NP_001293823.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CJF9
    Conserved Domains (1) summary
    pfam00520
    Location:416 → 642
    Ion_trans; Ion transport protein

  11. NM_001306891.3 → NP_001293820.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CLY7
    Conserved Domains (1) summary
    pfam00520
    Location:416 → 642
    Ion_trans; Ion transport protein

  12. NM_001306889.3 → NP_001293818.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CJF5
    Conserved Domains (1) summary
    pfam00520
    Location:428 → 654
    Ion_trans; Ion transport protein

  13. NM_171352.5 → NP_741413.2  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741413.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q688B2, Q6Q762
    Conserved Domains (1) summary
    pfam00520
    Location:449 → 654
    Ion_trans; Ion transport protein

  14. NM_001307703.3 → NP_001294632.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, U4PMX5
    Conserved Domains (1) summary
    pfam00520
    Location:389 → 594
    Ion_trans; Ion transport protein

  15. NM_068526.5 → NP_500927.3  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500927.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06AY5, Q688B3
    Conserved Domains (1) summary
    pfam00520
    Location:389 → 594
    Ion_trans; Ion transport protein

  16. NM_001306890.3 → NP_001293819.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6Q762, V6CKL6
    Conserved Domains (1) summary
    pfam00520
    Location:368 → 594
    Ion_trans; Ion transport protein
Nucleotide Protein
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