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htp-2 HORMA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177405, updated on 17-Oct-2024

Summary

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Official Symbol
htp-2
Official Full Name
HORMA domain-containing protein
Primary source
WormBase:WBGene00002033
Locus tag
CELE_Y73B6BL.2
See related
AllianceGenome:WB:WBGene00002033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of centriole-centriole cohesion. Located in lateral element. Orthologous to human HORMAD1 (HORMA domain containing 1) and HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See htp-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (6419522..6420898)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Exosome complex component RRP4 homolog Neighboring gene Nitrogen regulatory IIA protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene PUM-HD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion. Martinez-Perez E, et al. Genes Dev, 2008 Oct 15. PMID 18923085, Free PMC Article
  2. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. Sato-Carlton A, et al. PLoS Genet, 2020 Nov. PMID 33175901, Free PMC Article
  3. Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. Ferrandiz N, et al. Nat Commun, 2018 Feb 26. PMID 29483514, Free PMC Article
  4. HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Couteau F, et al. Genes Dev, 2005 Nov 15. PMID 16291647, Free PMC Article
  5. Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis. Schvarzstein M, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23401519, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of centriole-centriole cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HORMA domain-containing protein
NP_500981.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6419522..6420898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068580.8 → NP_500981.3  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500981.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XC8
    Conserved Domains (1) summary
    pfam02301
    Location:38 → 240
    HORMA; HORMA domain
Nucleotide Protein
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