U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

odr-8 Ufm1-specific protease [ Caenorhabditis elegans ]

Gene ID: 177417, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
odr-8
Official Full Name
Ufm1-specific protease
Primary source
WormBase:WBGene00018160
Locus tag
CELE_F38A5.1
See related
AllianceGenome:WB:WBGene00018160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables deUFMylase activity. Involved in several processes, including positive regulation of chemotaxis; protein localization to non-motile cilium; and response to ethanol. Part of protein-containing complex. Is expressed in hypodermis; intestine; and nervous system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See odr-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (6579836..6582704, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Methyltransf_21 domain-containing protein;Secreted protein Neighboring gene TraB domain-containing protein Neighboring gene DnaJ homolog subfamily C member 2 Neighboring gene Galectin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural basis for Ufm1 recognition by UfSP. Kim KH, et al. FEBS Lett, 2018 Jan. PMID 29251776
  2. The MPN domain of Caenorhabditis elegans UfSP modulates both substrate recognition and deufmylation activity. Ha BH, et al. Biochem Biophys Res Commun, 2016 Aug 5. PMID 27240952
  3. The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. Hertel P, et al. J Biol Chem, 2013 Apr 12. PMID 23449979, Free PMC Article
  4. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Dwyer ND, et al. Cell, 1998 May 1. PMID 9590179
  5. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Colin E, et al. Am J Hum Genet, 2016 Sep 1. PMID 27545681, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deUFMylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deUFMylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to non-motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Ufm1-specific protease
NP_001023188.1
  • Confirmed by transcript evidence
NP_001023189.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6579836..6582704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028017.4 → NP_001023188.1  Ufm1-specific protease [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023188.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86MF8, Q94218
    Conserved Domains (1) summary
    pfam07910
    Location:395 → 580
    Peptidase_C78; Peptidase family C78

  2. NM_001028018.2 → NP_001023189.1  Ufm1-specific protease [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94218
    Conserved Domains (1) summary
    pfam07910
    Location:381 → 566
    Peptidase_C78; Peptidase family C78
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94218.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools