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dnj-11 DnaJ homolog subfamily C member 2 [ Caenorhabditis elegans ]

Gene ID: 177419, updated on 2-Nov-2024

Summary

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Official Symbol
dnj-11
Official Full Name
DnaJ homolog subfamily C member 2
Primary source
WormBase:WBGene00001029
Locus tag
CELE_F38A5.13
See related
AllianceGenome:WB:WBGene00001029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Hsp70 protein binding activity and ribosome binding activity. Predicted to be involved in 'de novo' cotranslational protein folding. Located in cytosol. Is expressed in several structures, including intestine; muscle cell; nervous system; pharynx; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-11 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (6585871..6588186)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ufm1-specific protease Neighboring gene TraB domain-containing protein Neighboring gene Galectin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene Nematode Specific Peptide family, group B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic analysis of stress response against arsenic in Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2013. PMID 23894281, Free PMC Article
  2. Coordination of cell proliferation and cell fate determination by CES-1 snail. Yan B, et al. PLoS Genet, 2013 Oct. PMID 24204299, Free PMC Article
  3. Control of apoptosis by asymmetric cell division. Hatzold J, et al. PLoS Biol, 2008 Apr 8. PMID 18399720, Free PMC Article
  4. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
  5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' cotranslational protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational fidelity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DnaJ homolog subfamily C member 2
NP_501006.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6585871..6588186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068605.7 → NP_501006.1  DnaJ homolog subfamily C member 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501006.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94216
    Conserved Domains (4) summary
    smart00717
    Location:536 → 584
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG5269
    Location:61 → 441
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    cd00167
    Location:536 → 582
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:98 → 167
    DnaJ; DnaJ domain
Nucleotide Protein
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