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lec-11 Galectin [ Caenorhabditis elegans ]

Gene ID: 177420, updated on 2-Nov-2024

Summary

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Official Symbol
lec-11
Official Full Name
Galectin
Primary source
WormBase:WBGene00002274
Locus tag
CELE_F38A5.3
See related
AllianceGenome:WB:WBGene00002274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity and galactoside binding activity. Involved in innate immune response. Located in cytoplasm. Is expressed in intestine and rectal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lec-11 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (6588184..6590154, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ufm1-specific protease Neighboring gene TraB domain-containing protein Neighboring gene DnaJ homolog subfamily C member 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene Nematode Specific Peptide family, group B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB. Goswamy D, et al. Front Immunol, 2023. PMID 36860863, Free PMC Article
  2. The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2011. PMID 21963509
  3. Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine. Maduzia LL, et al. J Biol Chem, 2011 Feb 11. PMID 21115491, Free PMC Article
  4. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
  5. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. Nandakumar M, et al. PLoS Genet, 2008 Nov. PMID 19023415, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Galectin
NP_001023191.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6588184..6590154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028020.6 → NP_001023191.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94215, Q9GNP8
    Conserved Domains (1) summary
    pfam00337
    Location:11 → 140
    Gal-bind_lectin; Galactoside-binding lectin

RNA

  1. NR_131549.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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