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T05A12.4 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177453, updated on 2-Nov-2024

Summary

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Official Symbol
T05A12.4
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00020235
Locus tag
CELE_T05A12.4
See related
AllianceGenome:WB:WBGene00020235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Orthologous to human SHPRH (SNF2 histone linker PHD RING helicase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T05A12.4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
23
Sequence:
Chromosome: IV; NC_003282.8 (6887948..6897783)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Trehalase Neighboring gene ncRNA Neighboring gene Protein SPT2 homolog Neighboring gene ncRNA Neighboring gene SRCR domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Col_cuticle_N domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_001023359.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6887948..6897783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028188.5 → NP_001023359.1  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0J8
    Conserved Domains (4) summary
    COG0553
    Location:1429 → 1563
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    pfam00176
    Location:297 → 670
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1425 → 1537
    Helicase_C; Helicase conserved C-terminal domain
    pfam13923
    Location:1346 → 1392
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
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