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ruvb-2 RuvB-like 2 [ Caenorhabditis elegans ]

Gene ID: 177458, updated on 2-Nov-2024

Summary

Official Symbol
ruvb-2
Official Full Name
RuvB-like 2
Primary source
WormBase:WBGene00020687
Locus tag
CELE_T22D1.10
See related
AllianceGenome:WB:WBGene00020687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA helicase activity. Predicted to be involved in box C/D snoRNP assembly; chromatin remodeling; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in gonad. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ruvb-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (6917111..6919406, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Neighboring gene CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase Neighboring gene Transposase Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RuvB-like 2
NP_501067.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6917111..6919406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068666.6NP_501067.1  RuvB-like 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501067.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GZH2
    Conserved Domains (2) summary
    pfam06068
    Location:17408
    TIP49; TIP49 C-terminus
    cl21455
    Location:69122
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases