pgl-1 Guanyl-specific ribonuclease pgl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pgl-1
Official Full Name: Guanyl-specific ribonuclease pgl-1
Primary source: WormBase:WBGene00003992
Locus tag: CELE_ZK381.4
See related: AllianceGenome:WB:WBGene00003992
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA endonuclease activity and identical protein binding activity. Involved in P granule organization and germ-line stem cell division. Located in P granule. Is expressed in germ line and germline precursor cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (6974442..6977318, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study demonstrates that germ-granule components, PGL-1 and PGL-3, can serve as negative regulators of apoptosis not only in the germline but also in the soma in C. elegans.
Title: Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.
we show that removal of either of two critical P-granule components, PGL-1 or GLH-1, is sufficient to cause germ cells to express UNC-119::GFP and MYO-3 and to display RNA accumulation defects similar to those observed after depletion of P granules. Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate.
Title: Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline.
PGL-1 and PGL-3 control germline apoptosis in C. elegans.
Title: Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
we demonstrated that mutations in C. elegans epg-11 cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis
Title: Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
findings show FBF-1 and FBF-2 have different effects on target mRNAs; FBF-2 prevents translation; FBF-2 activity depends on PGL-1; PGL-1 is required to localize FBF-2 to perinuclear P granules and for efficient binding of FBF-2 to its mRNA targets
Title: The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells.
Data show that GLH-1 and its FG domain are not sufficient to form granules, but require factors like PGL-1 to nucleate the localized concentration of GLH proteins.
Title: P granules extend the nuclear pore complex environment in the C. elegans germ line.
Data show that the PGL proteins PGL-1 and PGL-3 serve as the scaffold for germ granule formation in Caenorhabditis elegans.
Title: PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans.
PGL-1, and at least PGL-3 functions redundantly with PGL-1 to ensure fertility in both sexes of C. elegans.
Title: The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK381.1 (e-PCR)
- UniSTS:307062

ZK381.4 (e-PCR)
- UniSTS:310481

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease T1 activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in P granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Guanyl-specific ribonuclease pgl-1

NP_001041066.1

Partially confirmed by transcript evidence

NP_001379582.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6974442..6977318 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392325.1 → NP_001379582.1 Guanyl-specific ribonuclease pgl-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TZQ3
NM_001047601.5 → NP_001041066.1 Guanyl-specific ribonuclease pgl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041066.1

Status: REVIEWED

UniProtKB/TrEMBL

Q304E5