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trxr-1 Thioredoxin reductase 1;thioredoxin-disulfide reductase [ Caenorhabditis elegans ]

Gene ID: 177466, updated on 2-Nov-2024

Summary

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Official Symbol
trxr-1
Official Full Name
Thioredoxin reductase 1;thioredoxin-disulfide reductase
Primary source
WormBase:WBGene00015553
Locus tag
CELE_C06G3.7
See related
AllianceGenome:WB:WBGene00015553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including epithelial cell; intestine; nervous system; pharynx; and vulva. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including TXNRD3 (thioredoxin reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trxr-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (7011954..7016586)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Peroxiredoxin Neighboring gene ncRNA Neighboring gene ZZ-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death. Arodin L, et al. Free Radic Biol Med, 2014 Aug. PMID 24863694
  2. Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans. Rohn I, et al. Metallomics, 2018 Jun 20. PMID 29770420, Free PMC Article
  3. Toxic-selenium and low-selenium transcriptomes in Caenorhabditis elegans: toxic selenium up-regulates oxidoreductase and down-regulates cuticle-associated genes. Boehler CJ, et al. PLoS One, 2014. PMID 24971995, Free PMC Article
  4. N-γ-(L-Glutamyl)-L-selenomethionine enhances stress resistance and ameliorates aging indicators via the selenoprotein TRXR-1 in Caenorhabditis elegans. Chang CH, et al. Mol Nutr Food Res, 2017 Aug. PMID 28133928
  5. Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans. Li W, et al. Mol Cells, 2012 Aug. PMID 22836943, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans
    Title: Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in Caenorhabditis elegans.
  2. Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
    Title: Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in ecdysis, collagen and cuticulin-based cuticle IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Thioredoxin reductase 1;thioredoxin-disulfide reductase
NP_001293761.1
  • Confirmed by transcript evidence
NP_001294239.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7011954..7016586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307310.3 → NP_001294239.1  Thioredoxin reductase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17745, Q9N2K1, Q9NJH3
    Conserved Domains (3) summary
    TIGR01438
    Location:173 → 667
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:353 → 426
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:537 → 648
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

  2. NM_001306832.3 → NP_001293761.1  thioredoxin-disulfide reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293761.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLN2
    Conserved Domains (1) summary
    TIGR01438
    Location:140 → 634
    TGR; thioredoxin and glutathione reductase selenoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17745.3

Gene LinkOut

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